Often referred to as the “Circulatory System”, vital nutrients, minerals, oxygen, and other essential molecules are pumped by the heart to every cell in the body through the intricate system of veins, arteries, and capillaries that comprise the core Cardiovascular System. This system additionally includes the primary lymphatic vessels and nodes and is often referred to in conjunction with, and sometimes includes, the Immune System due to motile leukocyte dependency on circulation and interstitial accessibility.
Magnesium’s application in the regulation of gated calcium-ion channels within muscles and at neuromuscular junctions, the requirements of magnesium in ATP production, as well as release of acetylcholine, makes it a crucial element in proper cardiovascular modulation and vascular-tone maintenance.
The mechanisms of excitation-contraction coupling for cardiac muscle is the same as that for skeletal muscle, but with a very different second effect specific to cardiac muscle particularly. For adequate excitation and contraction of cardio muscle fibers, large quantities of extra calcium ions are required at the time of action potential in the heart, without which the strength of cardiac muscle contraction would be considerably reduced due to its inability to store enough calcium to provide full contraction. Adequate use and channeling of calcium ions throughout every excitation, contraction, and rest phases within cardiac muscle depends on crucial intracellular magnesium concentrations in cardiac muscle tissue, as well as proper extracellular calcium concentrations in serum and other interstitial fluids. Because of cardiac muscles’ inability to store extra calcium, the role magnesium plays in regulating calcium re-uptake is essential to cardiac muscle health and endurance.
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